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Two-Probe Bone Affinity Sampler

$729.00$749.00

Catalogue number: BV345012

This sampler kit includes two imaging probes with different spectroscopic properties as well as variable bone affinities (AF647-RIS has stronger affinity than 5(6)-FAM-RISPC). The probes are fluorescent conjugates of risedronate, a widely used bisphosphonate drug in clinical applications, and its phosphonocarboxylate analogue. There is also an option of adding the calcein (a fluorescent molecule even lower bone affinity) in the kit. The kit can be used for simultaneous detection with co-dosing and studies on effects of bone affinity, and is a great, economical complement to the 3-probe bone affinity kit.

Kit Contents:

  • 24 nmol of AF647-RIS
  • 24 nmol of 5(6)-FAM-RISPC
  • 10 mg of Calcein
Please contact us for more details about the sampler kit: inquiry@biovinc.com

 

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Description
Spectroscopic Properties
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References
  • This sampler kit includes two imaging probes with different spectroscopic properties as well as variable bone affinities (AF647-RIS has stronger affinity than 5(6)-FAM-RISPC). The probes are fluorescent conjugates of risedronate, a widely used bisphosphonate drug in clinical applications, and its phosphonocarboxylate analogue. There is also an option of adding the calcein (a fluorescent molecule with even lower bone affinity) in the kit. The kit can be used for simultaneous detection with co-dosing and studies on effects of bone affinity, and is a great, economical complement to the 3-probe bone affinity kit.

     

    Spectroscopic properties of AF647-RIS:
    Maximum absorption wavelength (λmax (abs)): 648 nm
    Maximum emission wavelength (λmax (em)): 666 nm
    Extinction coefficient (M-1cm-1):  240,000 (0.1 M phosphate buffer, pH 7.0)

     

    Spectroscopic properties of 5(6)-FAM-RISPC:
    Maximum absorption wavelength (λmax (abs)): 493 nm
    Maximum emission wavelength (λmax (em)): 518 nm
    Extinction coefficient (M-1cm-1): 73,000 (0.1 M phosphate buffer, pH 7.2)

     

    *For laboratory use only. These products are intended for animal research only and not for use in humans.
  • Spectroscopic Properties

    Emission spectra of AF647-RIS (in 0.1 M phosphate buffer, pH 7.0) and AF647-RISPC (in 0.1 M phosphate buffer, pH 7.0).
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  • References